NEWS ニュース



Notice concerning sales launch date of a new brand “Ko” with CBD (Cannabidiol) as a core ingredient.

Premier Wellness Sciences Co., Ltd. (Headquartered in Minato-ku, Tokyo; Shinji Hosoyama, Chief Executive Officer; hereinafter “PWS”) is pleased to announce the launch of its new brand “Ko” with CBD*¹ (cannabidiol) as a core ingredient (hereinafter “Ko”), effective July 21st, 2022 (Thursday).

1. Background of Brand Development
During the 1990’s, scientists discovered a physiological system in the human and animal body called the endocannabinoid system (ECS) that regulates the body. The ECS consists of cannabinoids called “anandamide” and “2-AG” in the body, cannabinoid receptors “CB1” on neurons and cannabinoid receptors “CB2” on immune cells that bind to these cannabinoids, and naturally exists throughout the body. The ECS maintains important biological functions, such as appetite, pain, immune system support, emotional stabilization, motor function, growth and aging, neuroprotection, memory and cognitive functions, as well as cell-to-cell communication support. Recent studies have revealed that a weaker ECS, caused by external stress and aging, may lead to various diseases.

Due to an increasing number of research institutions in Japan and abroad that have completed studies suggesting that it regulates ECS, CBD, the core ingredient of Ko’s products, is expected to be consumed as a functional ingredient specifically in cosmetics and health food products.

In order to prepare for a sustainable, long-term growth, PWS has successfully developed and engineered an unprecedented supply chain, including stable supply of CBD raw material, development of optimal formulations with OEMs that specialize in physical property optimization technology incorporating DDS*³ technology DehydraTECH™*⁴ (a technology that increases the bioavailability (BA) of CBD according to the route of administration, application, etc. and shorten the onset time of efficacy) with the ultimate goal of improving safety, stability and efficacy of products containing cannabinoids*² like CBD.

In terms of sales channels, we will create our own e-commerce infrastructure and digital marketing campaign in collaboration with our parent company, Premier Anti-Aging Co., Ltd. (TSE Growth: 4934). For wholesale sales, we will work with PALTAC CORPORATION (TSE Prime: 8283) to expand our sales channels.

2. Brand overview
Ko supports the health and wellness of all people, regardless nationality, gender, or race, highlighted by our “All Wellness” concept. Ko brand focuses on the endocannabinoid system and circadian rhythm*⁵ as key elements of wellness. All our products will contain CBD and botanical extracts that target circadian rhythm conditions.
Our products aim to improve our endocannabinoid system and alleviate the body’s internal rhythmic conditions.

Brand Name Ko
Concept All Wellness
Core Ingredient CBD Cannabidiol
Supporting Ingredient Botanical extracts that support circadian rhythms
Market Launch Thursday, July 21st, 2022
Brand Site
*Accessible from July 21st, 2022 at 9 am
Announcement Site
Joint Research Professor. Hitoshi Sato, School of Pharmacy, Showa University

3. For interviews and inquiries regarding this release, please contact
Premier Wellness Science Co., Ltd.

As part of our measures to prevent the infection of the new coronavirus, our group is working by telework. Please contact us by using the above e-mail address for inquiries.
4. Regarding this release
The information contained in this news release is current as of the date of publication. It is subject to change without notice due to various factors. Please be aware of this in advance.

*1 CBD (cannabidiol)
One of the bioactive cannabinoid compounds, contained in industrial hemp.

*2 Cannabinoid
General term that describes active compounds found in industrial hemp. There are 114 different cannabinoid compounds discovered so far. On PubMed, the world’s largest medical, biological, pharmaceutical database provided by the National Library of Medicine (NLM), over 1000 research and studies related to cannabinoids are published on an annual basis.

*3 Drug delivery system (DDS)
A pharmaceutical technology that minimizse side effects, while maximizing drug efficacy by controlling the drug distribution in the body. It is classified as the following according to the drug to be used and the intended use; Promotion of drug absorption, sustained release performance to enhance drug sustainability, longevity of drugs with fast metabolism in the body, targeting performance to deliver drugs only to specific sites such as tissues and cells targeted.

*4 DehydraTECH™
A drug delivery system owned by Lexaria Bioscience Corp.(Nasdaq:LEXX). LEXX has agreed to exclusively supply its technology to PWS with sublicense rights. DehydraTECH™ can increase CBD absorption by 5 to 10 times, even up to 27 times, compared to industry-standard formulated products. Furthermore, many studies have confirmed that DehydraTECH™ reduces the onset of efficacy from 1 to 2 hours to few minutes.

*5 Circadian Rhythm
An important biological process that regulates our internal clock, roughly every 24 hours. Research has confirmed the gene that regulates this internal rhythm and its function. The Clock, Bmall, Per, and Cry genes are the main rhythmic genes that support gene transcription. It is believed that a negative feedback cycle is formed in the transcription/transition mechanism consisting of the gene product and the expression regulation site. The transcription is maintained by increasing or decreasing in a cycle of roughly 24 hours. This mechanism is the main biological rhythm oscillation for roughly 24 hours. This gene is found in almost all cells in the human body and each organ has its own unique rhythm. Furthermore, the gene not only maintains the internal biological clock, but also directly and indirectly contributes to the rhythm expressions differently, like a timer controlling on and off throughout the day. It efficiently maintains an optimal internal environment through this process. Today, reports are published frequently, claiming that environmental changes, such as stress, sleep deprivation, overeating, irregular diet, have been the main causes of poor lifestyle-related diseases and psychological conditions, suggesting the underlying relevance of circadian rhythm in their weakened health.

Notice concerning sales launch date of a new brand “Ko” with CBD (Cannabidiol) as a core ingredient